Partial differential equations (PDEs) with boundary conditions (Dirichlet or Neumann) defined on boundaries with simple geometry have been successfully treated using sigmoidal multilayer perceptrons in previous works. The article deals with the case of complex boundary geometry, where the boundary is determined by a number of points that belong to it and are closely located, so as to offer a reasonable representation. Two networks are employed: a multilayer perceptron and a radial basis function network. The later is used to account for the exact satisfaction of the boundary conditions. The method has been successfully tested on two-dimensional and three-dimensional PDEs and has yielded accurate results.